Tetrahydrofuran → HCID 66795818, compound

HRID 533689Notes

Reaction equation

HRID 533689 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[C:11]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=O)=[CH:4][CH:3]=1.C1COCC1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 66795997HCID 66795997, compound

Product 1

HCID 66795818HCID 66795818, compound

Procedure

Following the general procedure, reaction of 6b (3.70 g assayed, 12.0 mmol) with 1 M BH3 in THF (42.0 mL, 42.0 mmol) afforded 7b in an assay yield of 2.77 g (9.4 mmol, 78% assay yield, 99% peak area). A sample was concentrated in vacuo to an oil to provide the standard.

Sources & evidence

ORD record
ord-b1cc328dc1e44b26bae8f76833106507
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

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