Tetrahydrofuran → HCID 66795803, compound

HRID 533690Notes

Reaction equation

HRID 533690 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[C:11]([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=O)=[CH:4][CH:3]=1.C1COCC1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 66795640HCID 66795640, compound

Product 1

HCID 66795803HCID 66795803, compound

Procedure

Following the general procedure, reaction of 6c (3.55 g assayed, 12.0 mmol) with 1 M BH3 in THF (42.0 mL, 42.0 mmol) afforded 7c in an assay yield of 2.98 g (10.6 mmol, 88% assay yield, 99% peak area). A sample was concentrated in vacuo to an oil to provide the standard.

Sources & evidence

ORD record
ord-09deb89875964b83ad9fa79216f3be5e
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

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