Tetrahydrofuran → HCID 66796247, compound

HRID 533691Notes

Reaction equation

HRID 533691 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[C:11]([N:13]([CH3:15])[CH3:14])=O)=[CH:4][CH:3]=1.C1COCC1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:13]([CH3:15])[CH3:14])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 66795855HCID 66795855, compound

Product 1

HCID 66796247HCID 66796247, compound

Procedure

Following the general procedure, reaction of 6d (3.22 g assayed, 12.0 mmol) with 1 M BH3 in THF (42.0 mL, 42.0 mmol) afforded 7d in an assayed yield of 2.21 g (8.7 mmol, 73% assay yield, 99% peak area). A sample was concentrated in vacuo to an oil to provide the standard.

Sources & evidence

ORD record
ord-ed9559bfc4584f8288b38b642e40b64f
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

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