Tetrahydrofuran → HCID 66796176, compound

HRID 533692Notes

Reaction equation

HRID 533692 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=O)=[CH:4][CH:3]=1.C1COCC1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 66796076HCID 66796076, compound

Product 1

HCID 66796176HCID 66796176, compound

Procedure

Following the general procedure, reaction of 6e (4.20 g assayed, 13.55 mmol) with 1 M BH3 in THF (47.4 mL, 47.4 mmol) afforded 7e in an assay yield of 2.68 g (9.05 mmol, 67% assay yield, 100% peak area). A sample was concentrated in vacuo to an oil to provide the standard.

Sources & evidence

ORD record
ord-34d7b277b7fe4029a922ca6a2d1d8c0a
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

Loading…