Tetrahydrofuran → HCID 66796274, compound

HRID 533693Notes

Reaction equation

HRID 533693 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[C:11]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=O)=[CH:4][CH:3]=1.C1COCC1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 66796086HCID 66796086, compound

Product 1

HCID 66796274HCID 66796274, compound

Procedure

Following the general procedure, reaction of 6f (3.95 g assayed, 13.42 mmol) with 1 M BH3 in THF (40.3 mL, 40.3 mmol) afforded 7f in an assay yield of 3.15 g (11.25 mmol, 84% assay yield, 100% peak area). A sample was concentrated in vacuo to an oil to provide the standard.

Sources & evidence

ORD record
ord-5148bae4dbb54a95828b6b1018414f47
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

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