3(2H)-Pyridazinone → HCID 66796051, compound

HRID 533694Notes

Reaction equation

HRID 533694 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1.[N:18]1[NH:19][C:20](=[O:24])[CH:21]=[CH:22][CH:23]=1>>[N:12]1([CH2:11][C@H:9]2[CH2:10][C@@H:8]2[C:5]2[CH:6]=[CH:7][C:2]([N:19]3[C:20](=[O:24])[CH:21]=[CH:22][CH:23]=[N:18]3)=[CH:3][CH:4]=2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 681533(2H)-PyridazinoneHCID 66795818HCID 66795818, compound

Product 1

HCID 66796051HCID 66796051, compound

Procedure

Following the general procedure, reaction of 7b (2.67 g assayed, 9.08 mmol) with 3(2H)-pyridazinone (1.14 g, 11.8 mmol) afforded a solution of the free base of 8b in an assayed yield of 2.61 g (93% assay yield, 95% peak area).

Sources & evidence

ORD record
ord-693cccdb90a8489b994962b0e19ee625
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

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