3(2H)-Pyridazinone → HCID 66796057, compound

HRID 533695Notes

Reaction equation

HRID 533695 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:4][CH:3]=1.[N:17]1[NH:18][C:19](=[O:23])[CH:20]=[CH:21][CH:22]=1>>[CH2:13]([N:12]([CH2:11][C@H:9]1[CH2:10][C@@H:8]1[C:5]1[CH:6]=[CH:7][C:2]([N:18]2[C:19](=[O:23])[CH:20]=[CH:21][CH:22]=[N:17]2)=[CH:3][CH:4]=1)[CH2:15][CH3:16])[CH3:14]

Participants

3

Reactant 2

HCID 681533(2H)-PyridazinoneHCID 66795803HCID 66795803, compound

Product 1

HCID 66796057HCID 66796057, compound

Procedure

Following the general procedure, reaction of 7c (2.87 g assayed, 10.2 mmol) with 3(2H)-pyridazinone (1.27 g, 13.2 mmol) afforded a solution of the free base of 8c in an assayed yield of 2.55 g (84% assay yield, 93% peak area).

Sources & evidence

ORD record
ord-250c22adbd4f43d489ede88cd902747b
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

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