3(2H)-Pyridazinone → HCID 66795884, compound

HRID 533696Notes

Reaction equation

HRID 533696 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:12]([CH3:14])[CH3:13])=[CH:4][CH:3]=1.[N:15]1[NH:16][C:17](=[O:21])[CH:18]=[CH:19][CH:20]=1>>[CH3:13][N:12]([CH2:11][C@H:9]1[CH2:10][C@@H:8]1[C:5]1[CH:6]=[CH:7][C:2]([N:16]2[C:17](=[O:21])[CH:18]=[CH:19][CH:20]=[N:15]2)=[CH:3][CH:4]=1)[CH3:14]

Participants

3

Reactant 2

HCID 681533(2H)-PyridazinoneHCID 66796247HCID 66796247, compound

Product 1

HCID 66795884HCID 66795884, compound

Procedure

Following the general procedure, reaction of 7d (2.13 g assayed, 8.37 mmol) with 3(2H)-pyridazinone (1.05 g, 10.5 mmol) afforded a solution of the free base of 8d in an assayed yield of 1.57 g (5.8 mmol, 70% assay yield, 93% peak area).

Sources & evidence

ORD record
ord-b66ab8c4c6884d43872087eea135d712
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

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