3(2H)-Pyridazinone → HCID 66795981, compound

HRID 533697Notes

Reaction equation

HRID 533697 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH2:11][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1.[N:18]1[NH:19][C:20](=[O:24])[CH:21]=[CH:22][CH:23]=1>>[O:15]1[CH2:16][CH2:17][N:12]([CH2:11][C@H:9]2[CH2:10][C@@H:8]2[C:5]2[CH:6]=[CH:7][C:2]([N:19]3[C:20](=[O:24])[CH:21]=[CH:22][CH:23]=[N:18]3)=[CH:3][CH:4]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 681533(2H)-PyridazinoneHCID 66796176HCID 66796176, compound

Product 1

HCID 66795981HCID 66795981, compound

Procedure

Following the general procedure, reaction of 7e (2.59 g assayed, 8.75 mmol) with 3(2H)-pyridazinone (1.09 g, 11.37 mmol) afforded a solution of the free base of 8e in an assayed yield of 2.03 g (50% assay yield, 96% peak area).

Sources & evidence

ORD record
ord-dec1b2e1482a41139bb50385632ca5af
Source dataset
uspto-grants-2014_10
Patent number
US08853390B2

Reaction notes

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