HCID 86715106, compound → HCID 136377298, compound

HRID 533914Notes

Reaction equation

HRID 533914 reaction equation
COC1C=CC(C[O:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]3[S:16][C:17]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][N:19]=3)=[N:13][CH:14]=2)=CC=1>C(O)(C(F)(F)F)=O>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[S:16][C:17]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][N:19]=2)=[N:13][CH:14]=1

Participants

3

Reactant 1

HCID 86715106HCID 86715106, compound

Product 1

HCID 136377298HCID 136377298, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of methyl 2-(5-(4-methoxybenzyloxy)pyridin-2-yl)thiazole-5-carboxylate (1.10 g) in TFA (10 mL) was stirred at 80° C. for 2 hours. After the reaction was complete, the mixture was evaporated. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1:2 to pure EA) to provide the subtitle compound. MS ESI+: m/z=237 [M+H]+.

Workup

  1. customthe mixture was evaporated
  2. customThe residue was purified by silica gel column chromatography
  3. washeluting with ethyl acetate/petroleum ether (1:2 to pure EA)

Sources & evidence

ORD record
ord-c7f718b81a7448c5a6c2880486bcc761
Source dataset
uspto-grants-2014_10
Patent number
US08853412B2

Reaction notes

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