HCID 86715113, compound → HCID 136377299, compound

HRID 533923Notes

Reaction equation

HRID 533923 reaction equation
COC1C=CC(C[O:8][C:9]2[CH:10]=[CH:11][C:12]([C:15]3[S:16][C:17]([CH3:20])=[CH:18][N:19]=3)=[N:13][CH:14]=2)=CC=1>C(O)(C(F)(F)F)=O>[CH3:20][C:17]1[S:16][C:15]([C:12]2[N:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)=[N:19][CH:18]=1

Participants

3

Reactant 1

HCID 86715113HCID 86715113, compound

Product 1

HCID 136377299HCID 136377299, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 2-(5-(4-methoxybenzyloxy)pyridin-2-yl)-5-methylthiazole (2.0 g) in TFA (10 mL) was stirred at 80° C. for 2 hours. After the reaction was complete, the mixture was evaporated. The residue was purified by chromatography (silica gel, EA/PE 1:2 to EA) to provide the title compound. MS ESI+: m/z=193 [M+H]+.

Workup

  1. customthe mixture was evaporated
  2. customThe residue was purified by chromatography (silica gel, EA/PE 1:2 to EA)

Sources & evidence

ORD record
ord-0d75dd5b0da3498a8d242f72c3dc43ca
Source dataset
uspto-grants-2014_10
Patent number
US08853412B2

Reaction notes

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