Methanol → HCID 66751259, compound

HRID 534886Notes

Reaction equation

HRID 534886 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]([CH3:32])([CH3:31])[CH3:30])[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1)C1C=CC=CC=1.CO>[C].[Pd].O1CCCC1>[C:29]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[N:20]1[CH2:19][CH2:18][N:17]([C:15]([C:12]2[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=2)=[O:16])[CH2:22][CH2:21]1)([CH3:32])([CH3:30])[CH3:31]

Participants

5

Reactant 2

HCID 887MethanolHCID 66751021HCID 66751021, compound

Product 1

HCID 66751259HCID 66751259, compoundYield 100.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1-{[4-(benzyloxy)phenyl]carbonyl}-4-(2-tert-butylphenyl)piperazine obtained in Example 17 (1.3 g), palladium carbon (contains 50% H2O, 300 mg), methanol (120 mL), and tetrahydrofuran (30 mL) was stirred at room temperature under hydrogen atmosphere (5 atm). The mixture was filtered and evaporated under reduced pressure to provide the title compound (1.03 g, quant.) as a solid.

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-133385c3dc6c40e2b21a0ef825e74e29
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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