Trifluoroacetic acid → HCID 66792777, compound

HRID 535007Notes

Reaction equation

HRID 535007 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:29][CH2:28][N:27]([CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])[C:26]3=[O:38])=[CH:21][CH:20]=2)=[O:18])[CH2:13][CH2:12]1)([CH3:4])([CH3:3])[CH3:2].FC(F)(F)C(O)=O>>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:29][CH2:28][N:27]([CH2:30][C:31]([OH:33])=[O:32])[C:26]3=[O:38])=[CH:21][CH:20]=2)=[O:18])[CH2:13][CH2:12]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66792904HCID 66792904, compound

Product 1

HCID 66792777HCID 66792777, compoundYield 96.3%

Procedure

A mixture of tert-butyl [3-(4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}phenyl)-2-oxoimidazolidin-1-yl]acetate obtained in Example 211 (1.28 g, 2.46 mmol) and trifluoroacetic acid (5 mL) was stirred at room temperature for 4 h. Trifluoroacetic acid was removed in vacuo and water was added to the mixture. The resulting solid was collected, washed with water, diisopropyl ether and dried under reduced pressure to give a solid (1.1 g, 96%).

Workup

  1. customTrifluoroacetic acid was removed in vacuo and water
  2. additionwas added to the mixture
  3. customThe resulting solid was collected
  4. washwashed with water, diisopropyl ether
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-514a81ddc5f941758449d6276eeee75d
Source dataset
uspto-grants-2014_10
Patent number
US08853215B2

Reaction notes

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