Hydroxyphenylacetic acid → HCID 70975891, compound

HRID 535565Notes

Reaction equation

[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[OH:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][CH:21]=1>>[OH:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:28])=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 127Hydroxyphenylacetic acid

HCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70975891HCID 70975891, compound

Procedure

The product of Example 1B and 2-(4-hydroxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.30 (dd, J=7.9, 1.2 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.00 (m, 1H), 7.89-7.92 (m, 1H), 7.18 (s, 2H), 6.75 (d, 2H), 3.81-3.83 (m, 4H), 3.53 (s, 2H), 3.07-3.11 (m, 4H); MS (ESI−) M/Z 379 (M−H)−.

Sources & evidence

ORD record: ord-0dfaa5be9c3a47318348038768ec2593
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859549B2

Reaction notes

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