(3-Bromophenyl)acetic acid → HCID 70976170, compound

HRID 535575Notes

Reaction equation

HRID 535575 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[Br:19][C:20]1[CH:21]=[C:22]([CH2:26][C:27](O)=[O:28])[CH:23]=[CH:24][CH:25]=1>>[Br:19][C:20]1[CH:21]=[C:22]([CH2:26][C:27]([NH:1][N:2]2[N:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:18])=[O:28])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 74653(3-Bromophenyl)acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976170HCID 70976170, compound

Procedure

The product of Example 1B and 2-(3-bromophenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.60 (t, J=1.8 Hz, 1H), 7.49 (dt, J=7.8, 1.5 Hz, 1H), 7.39 (d, J=7.6 Hz, 1H), 7.34 (t, J=7.7 Hz, 1H), 3.83 (d, J=4.2 Hz, 4H), 3.69 (s, 2H), 3.09-3.11 (m, 4H); MS (ESI−) M/Z 441 (M−H)−.

Sources & evidence

ORD record
ord-12c8c5c5fb25444285c1a57d87ac7dc9
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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