(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid → HCID 70976049, compound

HRID 535582Notes

Reaction equation

HRID 535582 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[F:19][C:20]([F:32])([F:31])[C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](O)=[O:29])=[CH:23][CH:22]=1>>[N:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:18])[N:2]([NH:1][C:28](=[O:29])[CH2:27][C:24]3[CH:23]=[CH:22][C:21]([C:20]([F:31])([F:19])[F:32])=[CH:26][CH:25]=3)[N:11]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 118342(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Product 1

HCID 70976049HCID 70976049, compound

Procedure

The product of Example 1B and 2-[4-(trifluoromethyl)phenyl]acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (d, J=7.3 Hz, 1H), 8.04 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.72-7.75 (m, 2H), 7.60-7.62 (m, 2H), 3.80-3.83 (m, 6H), 3.03-3.14 (m, 4H); MS (ESI−) M/Z 431 (M−H)−.

Sources & evidence

ORD record
ord-a68270c043a742ed8fdce617512508c9
Source dataset
uspto-grants-2014_10
Patent number
US08859549B2

Reaction notes

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