反应详情

温度

55 °C

Triethylsilane (8.8 mL, 54.9 mmol) was added to a solution of 1-(1-acetylindolin-5-yl)-2-bromo-ethanone (1.9 g, 6.73 mmol) in trifluoroacetic acid (70 mL) at rt. The mixture was heated at 55° C. for 18 h, then cooled and concentrated under reduced pressure. The product was purified by flash chromatography (SiO2; hexane/EtOAc; 75/25). Yield: 1.2 g (67%).

1. temperaturecooled
2. concentrationconcentrated under reduced pressure
3. customThe product was purified by flash chromatography (SiO2; hexane/EtOAc; 75/25)