Potassium Carbonate → HCID 46223986, compound

HRID 535890Notes

Reaction equation

HRID 535890 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2=[C:9]([S:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][N:11]=[C:5]2[N:4]([CH2:19][C:20]([CH3:23])([CH3:22])[CH3:21])[C:3]1=[O:24].Br[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([N:33]2[CH:37]=[N:36][CH:35]=[N:34]2)=[CH:29][CH:28]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:33]1([C:30]2[CH:31]=[CH:32][C:27]([CH2:26][N:10]3[C:9]([S:12][C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[C:6]4[C:5]([N:4]([CH2:19][C:20]([CH3:21])([CH3:23])[CH3:22])[C:3](=[O:24])[N:2]([CH3:1])[C:7]4=[O:8])=[N:11]3)=[CH:28][CH:29]=2)[CH:37]=[N:36][CH:35]=[N:34]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27764891-(4-(bromomethyl)phenyl)-1H-1,2,4-triazoleHCID 178481361HCID 178481361, compound

Product 1

HCID 46223986HCID 46223986, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Crude 5-methyl-7-neopentyl-3-(phenylthio)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (40 mg, 0.12 mmol), 1-(4-(bromomethyl)phenyl)-1H-1,2,4-triazole (28 mg, 0.12 mmol) and K2CO3 (16 mg, 0.12 mmol) are suspended in 5 mL of anhydrous DMF. The reaction mixture is stirred at room temperature overnight, and then evaporated to dryness under reduced pressure. The residue is purified by silica gel column chromatography to give pure product as white solids. MS (ESI) m/z 502.2 [M+H]+.

Workup

  1. customevaporated to dryness under reduced pressure
  2. customThe residue is purified by silica gel column chromatography
  3. customto give pure product as white solids

Sources & evidence

ORD record
ord-d266d58e252547c09c4451a08d382d2e
Source dataset
uspto-grants-2014_10
Patent number
US08859564B2

Reaction notes

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