Ethyl Bromide → 2-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-5-{[(1-ethyl-2-oxo-1,2-dihydro-4-pyrimidinyl)oxy]methyl}benzonitrile

HRID 536184Notes

Reaction equation

HRID 536184 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:16]=[CH:15][C:14]([CH2:17][O:18][C:19]3[NH:20][C:21](=[O:25])[N:22]=[CH:23][CH:24]=3)=[CH:13][C:10]=2[C:11]#[N:12])=[CH:4][C:3]=1[C:26]([F:29])([F:28])[F:27].Br[CH2:31][CH3:32]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:16]=[CH:15][C:14]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][N:22]([CH2:31][CH3:32])[C:21](=[O:25])[N:20]=3)=[CH:13][C:10]=2[C:11]#[N:12])=[CH:4][C:3]=1[C:26]([F:27])([F:29])[F:28]

Participants

3

Reactant 2

HCID 6332Ethyl BromideHCID 573831812-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-5-{[(2-oxo-1,2-dihydro-4-pyrimidinyl)oxy]methyl}benzonitrile

Product 1

HCID 573831822-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-5-{[(1-ethyl-2-oxo-1,2-dihydro-4-pyrimidinyl)oxy]methyl}benzonitrile

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-{[(2-oxo-2,3-dihydro-4-pyrimidinyl)oxy]methyl}benzonitrile and bromoethane. LC-MS (ESI): m/z 450 [M+H]+; 4.11 min (ret time).

Workup

  1. custom4.11 min (ret time)

Sources & evidence

ORD record
ord-359bd690811b454988680386f21682e2
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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