反应详情

温度

160 °C

8-Methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (Step 3, 1.00 g, 0.002 mol) was dissolved in 1-methyl-2-pyrrolidinone (20 ml) and treated with sodium sulfide (0.76 g, 0.010 mol) and heated to 160° C. for 5 h. It was cooled, filtered from reaction rinsing with EtOAc. The solid was dissolved in a minimal amount of water and brought to pH=1 with 2N HCl, then back to pH=7 with 1N NaOH and filtered.

1. temperatureIt was cooled
2. filtrationfiltered from reaction
3. washrinsing with EtOAc
4. dissolutionThe solid was dissolved in a minimal amount of water
5. filtrationback to pH=7 with 1N NaOH and filtered