反应详情

温度

0 °C

81.2 ml (582.25 mmol) of triethylamine was added to a suspension of 46.2 g (264.66 mmol) of 2-chloro-5-fluoronicotinamide in dichloromethane (783 ml) and cooled to 0° C. While stirring, 41.12 ml (291.13 mmol) of trifluoroacetic acid anhydride was slowly added dropwise and stirred for a further 1.5 h at 0° C. The reaction solution was then washed twice with saturated aqueous sodium hydrogen carbonate solution (391 ml each time), dried and concentrated by vacuum evaporation.

1. stirringstirred for a further 1.5 h at 0° C
2. washThe reaction solution was then washed twice with saturated aqueous sodium hydrogen carbonate solution (391 ml each time)
3. customdried
4. concentrationconcentrated by vacuum evaporation