HCID 71285801, compound → HCID 71285885, compound

HRID 536490Notes

Reaction equation

HRID 536490 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][C:5]1[N:6]=[C:7]([C:14]([NH2:16])=O)[N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12>P(Cl)(Cl)(Cl)=O>[F:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][C:5]1[N:6]=[C:7]([C:14]#[N:16])[N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12

Participants

3

Reactant 1

HCID 71285801HCID 71285801, compound

Product 1

HCID 71285885HCID 71285885, compound

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Conditions

Temperature
120 °C

Procedure

150 ml of phosphoryl chloride was added to 9.100 g (33.67 mmol) of 8-(2-fluorobenzyl)imidazo[1,5-a]pyrimidine-6-carboxamide and it was stirred for 2 h at 120° C. The reaction mixture was concentrated in the rotary evaporator and the residue was mixed with water. The solid was filtered with suction, washed with a little water and dried under high vacuum. 8.02 g (92% of theor.) of the target compound was obtained.

Workup

  1. concentrationThe reaction mixture was concentrated in the rotary evaporator
  2. additionthe residue was mixed with water
  3. filtrationThe solid was filtered with suction
  4. washwashed with a little water
  5. customdried under high vacuum
  6. custom8.02 g (92% of theor.) of the target compound was obtained

Sources & evidence

ORD record
ord-e9ed9ab03a774aeca23e7e7f0d0fc13c
Source dataset
uspto-grants-2014_10
Patent number
US08859569B2

Reaction notes

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