HCID 67345519, compound → HCID 67345265, compound

HRID 536692Notes

Reaction equation

HRID 536692 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:12]3[CH2:19][CH2:18][CH:17]4[C:20]([CH3:22])([CH3:21])[CH:13]3[CH2:14][C:15]3[C:26]([O:27]C)=[CH:25][CH:24]=[CH:23][C:16]=34)=[O:11])=[CH:9][C:4]=2[NH:3][CH:2]=1>Br>[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:12]3[CH2:19][CH2:18][CH:17]4[C:20]([CH3:22])([CH3:21])[CH:13]3[CH2:14][C:15]3[C:26]([OH:27])=[CH:25][CH:24]=[CH:23][C:16]=34)=[O:11])=[CH:9][C:4]=2[NH:3][CH:2]=1

Participants

3

Reactant 1

HCID 67345519HCID 67345519, compound

Product 1

HCID 67345265HCID 67345265, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A solution of (3H-benzoimidazol-5-yl)-(10-methoxy-11,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-methanone (0.10 g) in hydrobromic acid (2 mL, 48% in water) is stirred at 80° C. for 24 h. After cooling to ambient temperature, the solution is concentrated under reduced pressure and the residue is purified by HPLC on reversed phase (MeCN/H2O/NH3).

Workup

  1. concentrationthe solution is concentrated under reduced pressure
  2. customthe residue is purified by HPLC on reversed phase (MeCN/H2O/NH3)

Sources & evidence

ORD record
ord-a9f1801613e5434d88bfac55a08cda14
Source dataset
uspto-grants-2014_10
Patent number
US08859580B2

Reaction notes

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