反应详情

To a stirred solution of cyanuric chloride (18.4 g, 10 mmol) in acetone (100 ml) and crushed ice (500 g), a mixture of triethylamine (30.0 g, excess) and morpholine (17.4 g, 20 mmol) was added at −10° C. After the addition, reaction mixture was stirred at room temperature and for 1 hour and diluted with 50 ml water. Separated white solid was filtered and washed with water. The white solid was dried and filtered. The crude product was found to be pure and taken to next step without purification. Yield: 25 g, 87%; (M+H) 286.7

1. additionwas added at −10° C
2. additionAfter the addition, reaction mixture
3. customSeparated white solid
4. filtrationwas filtered
5. washwashed with water
6. customThe white solid was dried
7. filtrationfiltered
8. customtaken to next step without purification