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HRID536828

反应详情

EQUATION

反应方程式

HRID 536828 反应方程式

REACTANTS

反应物

4
1,2-Ethanediamine, N,N,N'-trimethyl- 分子结构式
HCID67338

1,2-Ethanediamine, N,N,N'-trimethyl-

C5H14N2

Diisopropylethylamine 分子结构式
HCID81531

Diisopropylethylamine

C8H19N

Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1) 分子结构式
HCID2733084

Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1)

C11H16F6N5OP

4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid 分子结构式
HCID44516307

4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid

C25H27N7O5

PRODUCTS

产物

1
HCID 44516311 分子结构式
HCID44516311

未命名化合物

收率 50.2%

AUXILIARIES

试剂、催化剂与溶剂

1
N-Methyl-2-pyrrolidone 分子结构式
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

To the stirred solution of 4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzoic acid (150 mg; 0.297 mmol), Hunig's base (303 μL, 1.782 mmol), HBTU (563 mg, 1.485 mmol) in 2 mL of NMP was reacted according to example 68 with N1,N1,N2-trimethylethane-1,2-diamine (154 μL, 1.188 mmol) to give N-(2-(dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide as a white solid (88 mg, 50% yield); MS (ESI) m/z=590.2.