Iodoethane → 4-Ethoxy-2-nitroaniline

Temperature

60 °C

A 500 mL 3-neck flask fitted with a stir-bar, condenser, and an Ar inlet was charged with 4-amino-3-nitrophenol (12.0 g, 77.9 mmol), ethyl iodide (15.2 g, 8.00 mL, 97.3 mmol), LiOH.H2O (6.55 g, 156 mmol), and EtOH (120 mL). The resultant solution was heated at 60° C. overnight. Another 3 mL of ethyl iodide and 1 g of LiOH.H2O were added, and the mixture was stirred at 60° C. overnight again. The solution was cooled and partitioned with EtOAc (250 mL) and H2O (200 mL). The organic phase was washed with 1% aqueous LiOH (2×200 mL), H2O (200 mL), and brine (200 mL), filtered through phase separation paper, and concentrated in vacuo to a dark red solid. The crude solid was triturated with hexanes:EtOAc 8:1 (50 mL). The solid was filtered, pressed with rubber dam, and rinsed with hexanes (3×10 mL). The material was dried to give 10.7 g of 46a as a red solid (75%). 1H NMR (60 MHz, CDCl3): δ 7.5 (d, 1H), 7.0 (dd, 1H), 6.7 (d, 1H), 5.9 (bs, 2H), 4.0 (qt, 2H), 1.4 (t, 3H) ppm. HPLC analysis (15:10:75 H2O:A1:MeOH) showed a purity of 96% with a retention time of 4.2 min.

1. customA 500 mL 3-neck flask fitted with a stir-bar, condenser
2. temperatureThe solution was cooled
3. custompartitioned with EtOAc (250 mL) and H2O (200 mL)
4. washThe organic phase was washed with 1% aqueous LiOH (2×200 mL), H2O (200 mL), and brine (200 mL)
5. filtrationfiltered through phase separation paper
6. concentrationconcentrated in vacuo to a dark red solid
7. customThe crude solid was triturated with hexanes:EtOAc 8:1 (50 mL)
8. filtrationThe solid was filtered
9. washrinsed with hexanes (3×10 mL)
10. customThe material was dried

ORD record

ord-cf3803adf1b64f88b29ea3ab0b975dd3

Source dataset

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08859780B2