反应详情

To a stirred solution of trans-4-(2,4-Dioxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-ylmethyl)-cyclohexanecarboxylic acid methyl ester (1 mmol, 0.35 g) in DMF dry (6 mL) under argon was sequentially added K2CO3 (1.6 mmol, 0.22 g) and MeI (2.2 mmol, 140 μL). The mixture was stirred at room temperature overnight. Then H2O (10 mL) was added and the solution was loaded on a C18 cartridge, wash with water (3×5 mL) and then the desired product was eluted with MeOH. The solvent was removed under reduced pressure to give the pure titled compound (0.29 g, yield 80%).

1. washwash with water (3×5 mL)
2. washthe desired product was eluted with MeOH
3. customThe solvent was removed under reduced pressure