反应详情

To a solution of 4-chlorobenzonitrile (10.0 g, 73.0 mmol) in EtOH (250 mL) was added hydroxylamine hydrochloride (5.03 g, 73.0 mmol) and NaOH (2.90 g, 73.0 mmol). The resulting reaction mixture was refluxed for 15 h. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added EtOH and filtered. The filtrate was evaporated in vacuo and used as such for the next step (crude yield 12.0 g, 66%).

1. customThe resulting reaction mixture
2. temperaturewas refluxed for 15 h
3. customAfter the completion of the reaction (TLC monitoring)
4. concentrationthe mixture was concentrated
5. additionadded EtOH
6. filtrationfiltered
7. customThe filtrate was evaporated in vacuo