Butyl iodide → HCID 66851866, compound

HRID 538757Notes

Reaction equation

HRID 538757 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1.[I:9][CH2:10][CH2:11][CH2:12][CH3:13]>C1(C)C=CC=CC=1>[IH:9].[CH2:10]([N:6]1[C:5]([CH3:7])=[C:4]([CH3:8])[S:3][C:2]1=[NH:1])[CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 10962Butyl iodideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

Product 1

HCID 66851866HCID 66851866, compoundYield 43.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 2-amino-4,5-dimethylthiazole (2.56 g, 20 mmol) and iodobutane (2.6 mL, 22 mmol) in toluene (20 mL) was refluxed at 80° C. for 48 hours. The mixture was cooled to room temperature and the precipitated solid was filtered, washed with toluene and dried under reduced pressure to provide 2.7 g of crude product as the hydroiodide salt; MS (ESI+) m/z 185 (M+H)+.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe precipitated solid was filtered
  3. washwashed with toluene
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-b56cc3a72433445a846a20081028336c
Source dataset
uspto-grants-2014_10
Patent number
US08865753B2

Reaction notes

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