Triethylamine → HCID 57476519, compound

HRID 538949Notes

Reaction equation

HRID 538949 reaction equation
[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1.CCN(CC)CC.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C(Cl)Cl>[CH3:18][S:19]([O:7][CH2:6][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[C:9]([CH3:10])[CH:8]=1)(=[O:21])=[O:20]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 10987288(4-Bromo-3-methylphenyl)methanol

Product 1

HCID 57476519HCID 57476519, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of compound 2 (2.0 g, 9.95 mmol), Et3N (6.94 mL, 49.7 mmol), and CH2Cl2 (100 mL) was cooled to 0° C. and treated with methanesulfonyl chloride (1.54 mL, 19.9 mmol). The solution was stirred at room temperature for 3 hours. The volatiles were removed under reduced pressure and the resultant crude product was used without further purification.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customthe resultant crude product was used without further purification

Sources & evidence

ORD record
ord-99ecd2b1c796419f93e846b7ecfb79a7
Source dataset
uspto-grants-2014_10
Patent number
US08865914B2

Reaction notes

Loading…