反应详情

N-[2-[[[5-(Dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (100 g) was dissolved in isopropanol (800 ml) containing molar equivalent of hydrogen chloride at 40°-50° C. The solution was stirred further for 1 hr. The hydrochloride crystallized during this period. The product was filtered off, washed with isopropanol twice (100 ml each) and was dried at 40° C. under vacuum to give Form 1 ranitidine hydrochloride (106 g), m.p. 137°-138° C., DSC peak temperature=143.4° C., purity=99.6% (HPLC).

1. customThe hydrochloride crystallized during this period
2. filtrationThe product was filtered off
3. washwashed with isopropanol twice (100 ml each)
4. customwas dried at 40° C. under vacuum