反应详情

温度

5 °C

To a solution of 3-(6-amino-2-butoxy-8-methoxy-9H-purin-9-yl)propan-1-ol)(12.00 g, 40.63 mmol) in NMP (97.45 g) was added triethyamine (6.17 g, 90.65 mmol) and the mixture was cooled to 5° C. Thereto was dropped methanesulfonyl chloride (6.05 g, 52.82 mmol) and the mixture was stirred at 5° C. for 30 minutes, followed by adding a water (244.00 g). After stirring for 1 hour, the resulting crystal was filtered to give the subject compound (30.34 as a crude product). Purity: 98.39% (HPLC)

1. stirringAfter stirring for 1 hour
2. filtrationthe resulting crystal was filtered