反应详情

To a solution of bis(trichloromethyl) carbonate (50 mg, 0.17 mmol) in tetrahydrofuran (2.0 mL) was added pyridine (0.04 mL, 0.510 mmol) dropwise under ice-cooling. After stirring under ice-cooling for 30 min, 6-(methylamino)nicotinonitrile (68 mg, 0.510 mmol) was added and the mixture was stirred at room temperature for 2.5 hours. The precipitated solid was filtered off. The filtrate containing (5-cyanopyridin-2-yl)(methyl)carbamic chloride (I-28) was directly used for next step.

1. temperaturecooling
2. temperaturecooling for 30 min
3. stirringthe mixture was stirred at room temperature for 2.5 hours
4. filtrationThe precipitated solid was filtered off
5. additionThe filtrate containing (5-cyanopyridin-2-yl)(methyl)carbamic chloride (I-28)