HCID 86691369, compound → HCID 86691370, compound

HRID 539962Notes

Reaction equation

HRID 539962 reaction equation
C([N:8](CC1C=CC=CC=1)[C:9]1([CH2:13][NH:14][C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[CH2:12][O:11][CH2:10]1)C1C=CC=CC=1>CO.FC(F)(F)C(O)=O.[OH-].[OH-].[Pd+2]>[NH2:8][C:9]1([CH2:13][NH:14][C:15](=[O:20])[C:16]([F:17])([F:18])[F:19])[CH2:12][O:11][CH2:10]1

Participants

5

Reactant 1

HCID 86691369HCID 86691369, compound

Product 1

HCID 86691370HCID 86691370, compound

Reagents, catalysts & solvents 3

HCID 6422Trifluoroacetic acidCatalystHCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

To a solution of N-{[3-(dibenzylamino)oxetan-3-yl]methyl}-2,2,2-trifluoroacetamide (4.0 g, 10.57 mmol) in methanol (80 mL) was added 20% palladium hydroxide on carbon (0.8 g) and trifluoroacetic acid (one drop). The mixture was stirred at room temperature under hydrogen overnight and then filtered. The filtrate was concentrated in vacuo to afford the crude product as a white solid.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-4f30e10da06144389902f07483ca63e4
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Reaction notes

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