Ammonia → HCID 20320505, compound

HRID 540209Notes

Reaction equation

HRID 540209 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=2)[N:3]=1.[NH3:14]>O1CCCC1>[Cl:1][C:2]1[N:11]=[C:10]([NH2:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 142564832,4-Dichloro-6-methylquinazoline

Product 1

HCID 20320505HCID 20320505, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 2,4-dichloro-6-methylquinazoline (500 mg, 2.348 mmol) and a solution of ammonia in tetrahydrofuran (20 mL, 3.0 M) was stirred in an ice-bath for 2 hours. The resulting mixture was concentrated in vauco to afford 454 mg of the crude product as a white solid.

Workup

  1. concentrationThe resulting mixture was concentrated in vauco

Sources & evidence

ORD record
ord-31236d62cca54d449e2510febd29d9cc
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Reaction notes

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