反应详情

To a solution of tert-butyl [1-(aminomethyl)cyclopropyl]carbamate (0.92 g, 4.9 mmol) in tetrahydrofuran (50 mL) was added triethylamine (1.3 mL, 9.4 mmol) followed by 2,4-dichloro-6-methylquinazoline (1.0 g, 4.7 mmol) in portions at room temperature. After being stirred at room temperature overnight, the resultant mixture was concentrated in vacuo to remove 20 mL of solvent and then stirred vigorously with water (200 mL). The formed solid was collected by filtration and washed with water and ether, then dried in vacuo to afford 1.5 g of the product as a white powder.

1. concentrationthe resultant mixture was concentrated in vacuo
2. customto remove 20 mL of solvent
3. stirringstirred vigorously with water (200 mL)
4. filtrationThe formed solid was collected by filtration
5. washwashed with water and ether
6. customdried in vacuo