反应详情

温度

0 °C

5.14 g (27.4 mmol) of 2-phenylheptanenitrile are added to a suspension of 1.34 g of 60% NaH in 50 ml of DMF cooled to 0° C. After stirring for 30 minutes, 7.6 g (220 mmol) of paraformaldehyde are added portionwise. The reaction medium is left to stir at ambient temperature for 6 hours and then hydrolysed with ice and extracted with diethyl ether. The organic phase is washed with a saturated aqueous solution of sodium hydrogen carbonate, dried over sodium sulphate, filtered and evaporated under pressure. The crude product obtained is purified by silica gel chromatography (eluent 8/2 heptane/ethyl acetate). 4.24 g in the form of a pale yellow oil are obtained with a yield of 71%.

1. waitThe reaction medium is left
2. stirringto stir at ambient temperature for 6 hours
3. extractionhydrolysed with ice and extracted with diethyl ether
4. washThe organic phase is washed with a saturated aqueous solution of sodium hydrogen carbonate
5. dry with materialdried over sodium sulphate
6. filtrationfiltered
7. customevaporated under pressure