Hydrochloric Acid → HCID 66988493, compound

HRID 540399Notes

Reaction equation

HRID 540399 reaction equation
[OH-].[Na+].FC(F)(F)C(O)=O.[CH3:10][N:11]1[C:15]([CH2:16][CH2:17][C:18]([O:20]C)=[O:19])=[CH:14][N:13]=[CH:12]1.[ClH:22]>C1COCC1>[ClH:22].[CH3:10][N:11]1[C:15]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:14][NH:13][CH2:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66988452HCID 66988452, compound

Product 1

HCID 66988493HCID 66988493, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 ml of an aqueous solution of sodium hydroxide at 30% are added to a solution of 320 mg (1.13 mmol) of methyl 3-(3-methyl-3H-imidazol-4-yl)propionate tri-fluoroacetate in 10 ml of THF. The reaction medium is stirred at ambient temperature for 16 hours and then cooled to 0° C., and concentrated hydrochloric acid is added dropwise until pH 1 is obtained. After filtration, the filtrate is evaporated. 87 mg of 3-(3-methyl-1H-imidazol-4-yl)propionic acid hydrochloride are obtained with a yield of 39%.

Workup

  1. temperaturecooled to 0° C.
  2. customis obtained
  3. filtrationAfter filtration
  4. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-10e8d6ce58a849679f295579fd2a3760
Source dataset
uspto-grants-2014_10
Patent number
US08871187B2

Reaction notes

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