反应详情

温度

100 °C

A mixture of 2 g of 5-bromopyridine-2-carbaldehyde, 1.96 g of 3-fluorophenylboronic acid, 11.2 g of K2CO3, 160 ml of toluene, 60 ml of water, 60 ml of ethanol and 0.93 mg of tetrakis(triphenylphosphine)palladium(0) is stirred at 100° C. under argon for 2 hours. The solvents are evaporated and the residue is dispersed in 100 ml of water, and the product is extracted with 2 portions of 30 ml of ethyl acetate. The organic phase is washed with 30 ml of sat. brine, dried over sodium sulfate and concentrated. The resulting residue is recrystallized from 28 ml of isopropanol.

1. customThe solvents are evaporated
2. additionthe residue is dispersed in 100 ml of water
3. extractionthe product is extracted with 2 portions of 30 ml of ethyl acetate
4. washThe organic phase is washed with 30 ml of sat. brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. customThe resulting residue is recrystallized from 28 ml of isopropanol