Trifluoroacetic acid → HCID 71254375, compound

HRID 540647Notes

Reaction equation

HRID 540647 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[N:24]4[CH:19]([CH2:20][N:21](C([O-])=O)[CH2:22][CH2:23]4)[CH:18]4[C:28](=[O:33])[N:29]([CH3:32])[C:30](=[O:31])[CH:17]34)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>ClCCl>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH:16]3[N:24]4[CH:19]([CH2:20][NH:21][CH2:22][CH2:23]4)[CH:18]4[C:28](=[O:33])[N:29]([CH3:32])[C:30](=[O:31])[CH:17]34)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86676732HCID 86676732, compound

Product 1

HCID 71254375HCID 71254375, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

100 mg of tert-butyl (8-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl}-2-methyl-1,3-dioxodecahydro-2,5,7a-triazacyclopenta[a]indene-5-carboxylate (from Example 10) are dissolved in 9 ml of dichloromethane, and 3 ml of trifluoroacetic acid are added. The mixture is stirred at RT for 2 h, the solvent is then removed under reduced pressure and the crude product is purified by column chromatography (silica gel, MeOH:DCM).

Workup

  1. customthe solvent is then removed under reduced pressure
  2. customthe crude product is purified by column chromatography (silica gel, MeOH:DCM)

Sources & evidence

ORD record
ord-b59f036b73e64087be21d427872f8f83
Source dataset
uspto-grants-2014_10
Patent number
US08871798B2

Reaction notes

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