反应详情

温度

60 °C

Iron powder (320 mg, 5.8 mmol) was stirred in ethanol (12 mL) with 1 N HCl solution (0.6 mL, 0.6 mmol) and heated at 60° C. for 2 hours. 5 N aqueous Ammonium chloride solution (1.0 mL, 5.0 mmol) and 4-(2-bromo-5-methyl-4-nitrophenyl)morpholine (350 mg, 1.2 mmol) were added and the mixture was heated at 60° C. for 30 minutes. The mixture was filtered through celite and the collected solids were washed with ethanol. The combined filtrates were evaporated to give the desired compound (0.24 g, 75%). LCMS for C11H16BrN2O (M+H)+: m/z=271.0.

1. temperaturethe mixture was heated at 60° C. for 30 minutes
2. filtrationThe mixture was filtered through celite
3. washthe collected solids were washed with ethanol
4. customThe combined filtrates were evaporated