5-Bromo-2,4-dichloropyrimidine → tert-Butyl [3-(2-{3-[(5-bromo-2-chloropyrimidin-4-yl)amino]phenyl}ethyl)phenyl]carbamate

HRID 541734Notes

Reaction equation

HRID 541734 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[NH2:10][C:11]1[CH:12]=[C:13]([CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])[CH:22]=[CH:23][CH:24]=2)[CH:14]=[CH:15][CH:16]=1>>[Br:1][C:2]1[C:3]([NH:10][C:11]2[CH:12]=[C:13]([CH2:17][CH2:18][C:19]3[CH:20]=[C:21]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:30])([CH3:29])[CH3:31])[CH:22]=[CH:23][CH:24]=3)[CH:14]=[CH:15][CH:16]=2)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 2899735-Bromo-2,4-dichloropyrimidineHCID 57962516tert-Butyl {3-[2-(3-aminophenyl)ethyl]phenyl}carbamate

Product 1

HCID 57962319tert-Butyl [3-(2-{3-[(5-bromo-2-chloropyrimidin-4-yl)amino]phenyl}ethyl)phenyl]carbamateYield 70%

Procedure

This compound was prepared according to the procedure of Example B5, step G using 5-bromo-2,4-dichloropyrimidine and tert-butyl {3-[2-(3-aminophenyl)ethyl]phenyl}carbamate as the starting materials in 70% yield. LCMS calculated for C23H25BrClN4O2 (M+H)+: m/z=503.1, 505.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-556e2647bd9b4a50913b8fd9f0dbd523
Source dataset
uspto-grants-2014_10
Patent number
US08871753B2

Reaction notes

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