反应详情

A mixture of 5.0 g (0.016 mol) of product of Example 35, 4.52 g (0.0362 mol) of 2,6-lutidine and 34 ml of phosphorus oxychloride was held at reflux for 20 hours and concentrated in vacuo. The residue was quenched with water and extracted with ether. The ether extract was washed successively with 10% K2CO3 and water, dried (CaSO4) and concentrated in vacuo to give 3.06 g (57.8%) of product as a brown oil, nD25 1.4313.

1. temperatureat reflux for 20 hours
2. concentrationconcentrated in vacuo
3. customThe residue was quenched with water
4. extractionextracted with ether
5. extractionThe ether extract
6. washwas washed successively with 10% K2CO3 and water
7. dry with materialdried (CaSO4)
8. concentrationconcentrated in vacuo