Glycerol → Sorbitol

HRID 542155Notes

Reaction equation

HRID 542155 reaction equation
[Na].[OH2:2].[OH:3][CH2:4][CH:5]([CH2:7][OH:8])[OH:6]>>[OH:3][CH2:4][C@@H:5]([C@H:7]([C@@H:7]([C@@H:5]([CH2:4][OH:3])[OH:6])[OH:2])[OH:8])[OH:6]

Participants

4

Reactant 3

HCID 753GlycerolHCID 962WaterHCID 5360545Sodium

Product 1

HCID 5780Sorbitol

Procedure

A high speed propeller mixer provided with a scraper was charged with the PEG-400, and the cross-linked CMC sodium was added, while stirring. After all lumps were broken up and a uniform slurry was obtained, the ground limestone was added in portions, and stirring was continued until all of the solids were suspended. The resulting slurry was homogenized and dearated and then filled into #11 oblong A size soft gelatin capsules by means of a rotary die encapsulator. The shell of the capsules was formed from gelatin, water, sorbitol and glycerin, and contained vanillin flavoring agent and titanium dioxide opacifier.

Workup

  1. customA high speed propeller mixer provided with a scraper
  2. customwas obtained
  3. additionthe ground limestone was added in portions
  4. stirringstirring
  5. stirringThe resulting slurry was homogenized
  6. additionfilled into #11 oblong A size soft gelatin capsules by means of a rotary die encapsulator

Sources & evidence

ORD record
ord-7f0ceade14ff4c92b716752f7263623c
Source dataset
uspto-grants-1987_04
Patent number
US04656028

Reaction notes

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