Hydrogen Bromide → 6-(Aminomethyl)pyridin-2(1H)-one hydrobromide

HRID 542263Notes

Reaction equation

HRID 542263 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9]C)[N:4]=1.[BrH:11]>>[BrH:11].[NH2:1][CH2:2][C:3]1[NH:4][C:5](=[O:9])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 13882973(6-Methoxypyridin-2-yl)methanamine

Product 1

HCID 135635896-(Aminomethyl)pyridin-2(1H)-one hydrobromide

Procedure

The crude product from Example 2 was combined with 10 ml of 48% hydrobromic acid, and the resulting mixture was heated at its reflux temperature for one hour. Evaporation to dryness provided 6-aminomethyl-2(1H)-pyridone hydrobromide as a water-soluble solid. The structural assignment was supported by infrared and nuclear magnetic resonance spectral analyses.

Workup

  1. temperaturethe resulting mixture was heated at its
  2. temperaturereflux temperature for one hour
  3. customEvaporation to dryness

Sources & evidence

ORD record
ord-1a9f767402184eff825e95da8669c952
Source dataset
uspto-grants-1987_04
Patent number
US04656285

Reaction notes

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