Hydrochloric Acid → methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride

HRID 542370Notes

Reaction equation

HRID 542370 reaction equation
[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([OH:7])=[O:6].[CH3:13]O>>[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([O:7][CH3:13])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 12879199(2RS,3S)-3-amino-2-hydroxy-5-methylhexanoic acid

Product 1

HCID 13746619methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride

Procedure

Hydrogen chloride was passed into a solution 110 mg of (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoic acid in 10 ml of methanol under ice-cooling, and the mixture was stirred overnight. The reaction mixture was evaporated to dryness under reduced pressure to obtain 150 mg of methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride as a white powder.

Workup

  1. temperaturecooling
  2. customThe reaction mixture was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-1c24ddd1af8940dd8558ad7229b1883a
Source dataset
uspto-grants-1987_04
Patent number
US04656269

Reaction notes

Loading…