反应详情

5-(4-Nitrophenyl)-2-(1H)-pyrazinone (0.1 g) was warmed with hydrazine hydrate (1 ml) in 50% aqueous ethanol (2.5 ml). Water (about 3 ml) was added sufficient to provide a clear solution. The mixture was allowed to cool slightly and 10% Palladium on charcoal (0.01 g) added as a slurry in a small amount of water. The well-stirred mixture was re-heated for 2 minutes, stirred without heating for 2 minutes, cooled and filtered. The filtrate was evaporated under reduced pressure to give a residue which was suspended in a little water. Dilute hydrochloric acid was added to pH6; the pale yellow solid was collected and washed with water to afford 5-(4-aminophenyl)-2(1H)-pyrazinone (0.06 g).

1. customto provide a clear solution
2. temperatureto cool slightly
3. temperatureThe well-stirred mixture was re-heated for 2 minutes
4. temperaturewithout heating for 2 minutes
5. temperaturecooled
6. filtrationfiltered
7. customThe filtrate was evaporated under reduced pressure
8. customto give a residue which
9. customthe pale yellow solid was collected
10. washwashed with water