N-(2-aminoethyl)acetamide → HCID 13853582, compound

HRID 542468Notes

Reaction equation

HRID 542468 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=2)=[CH:6][CH:5]=1)=[C:2]=[O:3].[C:17]([NH:20][CH2:21][CH2:22][NH2:23])(=[O:19])[CH3:18]>CN(C)C=O>[C:17]([NH:20][CH2:21][CH2:22][NH:23][C:2](=[O:3])[NH:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=2)=[CH:6][CH:5]=1)(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 66082N-(2-aminoethyl)acetamideHCID 202086615-(4-Isocyanatophenyl)pyrazin-2(1H)-one

Product 1

HCID 13853582HCID 13853582, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a manner similar to Example 13b, 5-[4-(isocyanato)phenyl]-2(1H)-pyrazinone is reacted with 2-acetamidoethylamine (1 g) in dimethylformamide (5 ml) for 17 hours at room temperature to form the title compound, m.p. 238°-44° C.; δ(DMSO-d6) 1.80 (s, 3H, COCH3), 7.94, 8.08 (2s, 2H, pyrazinone H's).

Sources & evidence

ORD record
ord-e5cf6e6893fe40e1bddee6f60ee1a7e3
Source dataset
uspto-grants-1987_04
Patent number
US04657906

Reaction notes

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