Hydroxyamine hydrochloride → HCID 13732598, compound

HRID 542557Notes

Reaction equation

HRID 542557 reaction equation
[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]([C:13](=O)[C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=3)[C:11]([OH:12])=[C:6]2[CH:5]=[N:4]1)[CH3:2].Cl.[NH2:23]O>N1C=CC=CC=1>[CH2:1]([N:3]1[C:7]2=[N:8][CH:9]=[C:10]3[C:13]([C:14]4[CH:15]=[C:16]([CH3:20])[CH:17]=[CH:18][CH:19]=4)=[N:23][O:12][C:11]3=[C:6]2[CH:5]=[N:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 178463022HCID 178463022, compound

Product 1

HCID 13732598HCID 13732598, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-Ethyl-4-hydroxy-5-(3-methylbenzoyl)-1H-pyrazolo[3,4-b]pyridine (4.25 g) was refluxed overnight in 75 ml of pyridine containing 4.5 g of hydroxylamine hydrochloride. The pyridine was then removed under reduced pressure and the residue triturated with 5% hydrochloric acid. The product was then filtered off and recrystallized from methanol to give 2.63 g of analytically pure product, mp 122°-123° C.

Workup

  1. customThe pyridine was then removed under reduced pressure
  2. customthe residue triturated with 5% hydrochloric acid
  3. filtrationThe product was then filtered off
  4. customrecrystallized from methanol
  5. customto give 2.63 g of analytically pure product, mp 122°-123° C.

Sources & evidence

ORD record
ord-a9269513d4d3478eb61f8c2e2c01bd76
Source dataset
uspto-grants-1987_04
Patent number
US04658029

Reaction notes

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