反应详情

31.9 g of acemetacin allyl ester, 100 ml of toluene, 2.3 g of triphenylphosphine and 0.75 g of palladium on charcoal (5% strength) are taken as an initial charge, under nitrogen. 11.9 g of piperidine are added dropwise, with stirring, and the mixture is then stirred for a further 3 hours at 90° C. It is filtered hot and the catalyst is rinsed with hot toluene. The filtrate is evaporated, the residue is taken up in methylene chloride (about 300 ml) and this solution is washed with half-concentrated hydrochloric acid (100 ml) and then with water. After removal of the solvent in vacuo, the residue is recrystallized from toluene.

1. additionan initial charge, under nitrogen
2. stirringthe mixture is then stirred for a further 3 hours at 90° C
3. filtrationIt is filtered hot
4. washthe catalyst is rinsed with hot toluene
5. customThe filtrate is evaporated
6. washthis solution is washed with half-concentrated hydrochloric acid (100 ml)
7. customAfter removal of the solvent in vacuo
8. customthe residue is recrystallized from toluene